Zazie Beetz
Dottie (voice)
Ken Jeong
Clarance (voice)
Jim Jefferies
Burnie (voice)
Catherine O'Hara
Alma (voice)
Reggie Watts
Hoss / Ernest Shackleton (voice)
Henry Winkler
Jepson (voice)
Alex Borstein
Mali (voice)
Benedict Wong
Dr. Chung (voice)
Julia Chan
Mrs. Sun / Little Girl (voice)
Tom Hollander
Charles Darwin (voice)
Richard Kind
Wally (voice)
Nick Frost
Captain (voice)
Sydney Malmberg Liu
Bo (voice)
Maria Bamford
Bo's Mom (voice)
Raymond S. Persi
That Guy / Booby (voice)
David Silverman
Cyclops / Donut Store Clerk (voice)
Kelly Hu
News Reporter (voice)
Tom Kenny
Mozart / Sled Dogs (voice)
Jason Hightower
Narrator / Sled Dogs (voice)
Kevin Michael Richardson
Sled Dogs (voice)
Brenden P. Hill
Baseball Announcer (voice)
Wilhelm Boyens
Additional Voices