Nick Kroll
Nick Birch / Maury the Hormone Monster / Lola / Coach Steve / Ladybug (voice)
John Mulaney
Andrew Glouberman (voice)
Jessi Klein
Jessi Glaser (voice)
Jason Mantzoukas
Jay Bilzerian (voice)
Jenny Slate
Missy Foreman-Greenwald (voice)
Fred Armisen
Elliot Birch (voice)
Maya Rudolph
Diane Birch / Connie the Hormone Monstress (voice)
Jordan Peele
Ghost of Duke Ellington (voice)
Gina Rodriguez
Gina Alvarez (voice)
Michaela Watkins
Cantor Dina Reznick (voice)
Jon Daly
Judd Birch (voice)
Kat Dennings
Leah Birch (voice)
Andrew Rannells
Matthew (voice)
Richard Kind
Marty Glouberman (voice)
Natasha Lyonne
Suzette (voice)
Zachary Quinto
Aiden (voice)
June Diane Raphael
Devin (voice)
Jessica Chaffin
Shannon Glaser (voice)